Pre-Altitude Serum Ferritin Levels and Daily Oral Iron Supplement Dose Mediate Iron Parameter and Hemoglobin Mass Responses to Altitude Exposure.

... males, serum ferritin: 30.1 ± 5.3 μgL-1; 16 females, serum ferritin: 29.7 ± 3.4 μgL-1) met the criteria for Stage 1 iron deficiency. Six athletes met the criteria for Stage 2 iron deficiency (2 males, serum ferritin: 17.4 ± 0.7 μgL-1; 4 females, serum ferritin: 15.2 ± 3.7 μgL-1) and one female athlete met the criteria for Stage 3 iron deficiency (serum ... iron status was classified based on their pre-altitude exposure serum ferritin levels. Iron deficiency was categorised into three stages: Stage 1 (iron deficiency): serum ferritin 16%; Stage 2 (iron deficient erythropoiesis): serum ferritin 16%; Stage 3: serum ferritin
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Changes in Serum NT-Pro BNP and Left Atrial BNP Levels after Percutaneous Transvenous Mitral Commissurotomy in Sinus Rhythm Versus Atrial Firilation

... undergoing PTMC were enrolled. We evaluated the serum NT-Pro BNP levels before and 24 hours after PTMC. BNP levels were also measured from the blood samples obtained from LA before and 20 minutes after the procedure. Changes in biomarkers were assessed based on heart rhythm and success of the procedure. Results: While serum NT-Pro BNP levels showed significant ... biomarker levels in LA precede serum changes, we postulated that LA sampling could provide an early indication for the success of the procedure and could offer immediate guidance for predicting favourable results. We sought to evaluate the BNP levels from left atrium (LA) before and 20 minutes after the procedure and serum NT-pro BNP levels before and ... NT-proBNP levels are shown to correlate positively with the severity of the stenosis in patients with MS. Following successful correction of the stenotic valve or its replacement the serum levels of this biomarker reduce significantly.5 Since PTMC causes rapid decreases in LA pressures and subsequent decreases in pulmonary artery pressure, it is conceivable that
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Effects of a honeybee sting on the serum free amino acid profile in humans.

... in the serum of the beekeepers directly after a bee sting . mean concentration in the serum of the beekeepers after at least six weeks since the last sting): Glu (d.value = 2.717), 3MHis (d.value = 1.155). Significant negative compounds (i.e. mean concentration in the serum of the beekeepers directly after a bee sting , mean concentration in the serum ... Issue 7 | e103533 Effects of a Honeybee Sting on the Serum Free Amino Acid Profile Figure 2. Three-dimensional (3D) partial least squares discriminant analysis separation using amino acids concentration-based metabolomics measurements in the serum of the beekeepers directly after a bee sting vs. the serum of the beekeepers after at least six weeks since ... spectrometrybased serum metabolite profiling is a promising technique to analyze complex metabolic alterations, which may broaden the understanding of the human body response to a honeybee sting. 11 July 2014 | Volume 9 | Issue 7 | e103533 Effects of a Honeybee Sting on the Serum Free Amino Acid Profile Thus, determination of serum AAs sheds a new
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Sero-diagnosis of Mycobacterium avium complex lung disease using serum immunoglobulin A antibody against glycopeptidolipid antigen in Taiwan.

... IU/ml, p=0.009) and patients with malignancy had lower serum GPL IgA levels than those without (0.40 vs. 4.70 IU/ml, p=0.018). Within the MAC-LD group, patients with high smear grade had higher serum MAC-GPL IgA levels than those with low smear grade and negative smear (7.89 vs. 3.41 IU/mL, p=0.039). The MAC-GPL IgA serum level was borderline higher in 46 MACLD ... were older and 32% of them had an underlying co-morbidity. By logistic regression, serum MAC-GPL IgA level was an independent predictor of MAC-LD among the study subjects and those with culture-positive specimens for MAC. By the receiver operating characteristic curve, serum MAC-GPL IgA had a good power to discriminate MAC-LD from MAC contamination. ... analysis. Conclusions: Measurement of serum anti-MAC-GPL IgA level is useful for the diagnosis of MAC-LD. However, its implement in clinical practice for immuno-compromised hosts needs careful consideration. Citation: Shu C-C, Ato M, Wang J-T, Jou R, Wang J-Y, et al. (2013) Sero-Diagnosis of Mycobacterium avium Complex Lung Disease Using Serum Immunoglobulin A Antibody
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Pigmentation and vitamin D metabolism in Caucasians: low vitamin D serum levels in fair skin types in the UK.

... backgrounds [11,12,13] rather than within Caucasian cohorts. The influence of sun exposure and sunbed exposure on vitamin D serum levels within Caucasian populations is also poorly studied. This study’s aim was to investigate the relationship between vitamin D serum levels, sun exposure and skin type in a large population based study in the UK. Introduction Sun exposure ... and psychiatric diseases [3,4,5,6]. More recent studies have also shown an association between low serum 25(OH)D levels and metabolic syndrome characterised by abdominal obesity, raised blood pressure and triglycerides with low HDL cholesterol [7]. Vitamin D serum levels are influenced mainly by sun exposure and to a lesser extent by diet[8]. Advice about ... 0.001 after adjustment for age, season of sampling, BMI, total number of weeks abroad and sunbed use). Figure 1 shows the median levels of serum 25(OH)D according to skin type. 45% of skin type 1 subjects had low serum 25(OH)D compared to 28% in the skin type 4. When winter 25(OH)D levels were measured, the differences were more marked- low 25(OH)D levels
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Serum uric acid and subsequent cognitive performance in patients with pre-existing cardiovascular disease.

... have declared that no competing interests exist. PLOS ONE | DOI:10.1371/journal.pone.0120862 March 20, 2015 1 / 11 Serum Uric Acid and Cognitive Performance Introduction There are a plethora of epidemiological studies linking high serum uric acid (UA) levels with increased risk of vascular disease [1–3]. High UA levels are also associated with major ... JM, Kim HC, Cho HM, Oh SM, Choi DP, Suh I. Association between serum uric acid level and metabolic syndrome. J Prev Med Public Health. 2012; 45:181–187. doi: 10.3961/jpmph.2012.45.3.181 PMID: 22712045 7. Schretlen DJ, Inscore AB, Vannorsdall TD, Kraut M, Pearlson GD, Gordon B, et al. Serum uric acid and brain ischemia in normal elderly adults. Neurology. ... March 20, 2015 9 / 11 Serum Uric Acid and Cognitive Performance 10. Chen H, Mosley TH, Alonso A, Huang X. Plasma urate and Parkinson's disease in the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol. 2009; 169:1064–1069. doi: 10.1093/aje/kwp033 PMID: 19299404 11. Euser SM, Hofman A, Westendorp RG, Breteler MM. Serum uric acid and cognitive
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Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile.

... subjects Association of serum FGF-21 levels with adverse lipid metabolism and insulin resistance As shown in Table 2 and Figure 2, a significant positive association of serum FGF-21 levels with triglyceride and apolipoprotein B100 (r = 0.365, P,0.001; r = 0.227, P = 0.002, Figure 1. Serum FGF-21 concentrations in subjects with CHD and normal controls. A, Serum FGF-21 ... research subjects. In addition, serum FGF-21 levels correlated with fasting glucose, fasting insulin as well as HOMA-IR after adjustment for BMI, but no significant correlation was found between serum FGF-21 levels and HOMA-IS. Serum FGF-21 levels are independently associated with ApoA1, TG and fasting glucose To determine whether serum FGF-21 was independently associated ... control subjects. Serum FGF-21 level and levels of fasting blood glucose; triglyceride; apolipoprotein B100; HOMA-IR; insulin; total cholesterol; HDL-cholesterol; LDL-cholesterol; and C-reactive protein were measured. We found that median serum FGF-21 levels were significantly higher in CHD than that of control subjects (P,0.0001). Serum FGF-21 levels
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Subject-specific increases in serum S-100B distinguish sports-related concussion from sports-related exertion.

... or abnormal behavior. Methods for obtaining and handling serum were identical at both sites. Four milliliters of venous blood was drawn into sterile Vacuatiner serum separator tubes and immediately placed on 0uC ice. Within 60 minutes, the blood was centrifuged (3000 rpm, 10 minutes), and the serum separated and stored at 280uC until sample analysis. Thirty ... post-exertion serum samples. All of these samples were analyzed for S100B. Six of these athletes suffered a SRC during the study period (Table 1). A total of 306 Rochester athletes agreed to participate, providing baseline (but not post-exertion) serum samples. Sixteen of these athletes suffered a SRC during the study period. Only the serum samples ... electrochemiluminescent reaction and the resultant light emission was measured using a photomultiplier. Serum S100B concentrations were reported as mg/L of serum and reported as mean values 6 SD. Reference range of S100B is 0.02 to 0.15 mg/L [23]. Analysis Serum S100B concentrations before and after SRC, as well as before and after non-contact exertion,
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Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose.

... effects of a 2 hour 75 g oral glucose tolerance test (OGTT) on serum cartonectin concentrations in T2DM subjects. Design: Cross-sectional study [newly diagnosed (first discovery, not on any treatments) T2DM (n = 47) and control (n = 63) subjects]. Serum cartonectin was measured by ELISA. Results: Serum cartonectin concentrations were significantly lower ... = 47). In control subjects (n = 63), serum cartonectin was significantly negatively correlated with CRP, and significantly positively correlated with insulin, HOMA-IR and leptin. However, when subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P.0.05). Finally, serum cartonectin concentrations were ... doi:10.1371/journal.pone.0112931.t001 serum cartonectin was significantly negatively correlated with CRP, and significantly positively correlated with insulin, HOMAIR and leptin [Table 2]. However, when subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P.0.05). Discussion We report for the first time that serum cartonectin
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Label-free LC-MSe in tissue and serum reveals protein networks underlying differences between benign and malignant serous ovarian tumors.

... overlap between differentially expressed protein sets in serum and tissue, APOA1 and Serotransferrin were significantly lower expressed in both serum and cancer tissue samples, suggesting a tissue-derived effect in serum. Pathway and subsequent interactome analysis also highlighted common regulators in serum and tissue samples, suggesting a yet unknown role ... | e108046 Label-Free LC-MSe in Tissue and Serum of Serous Ovarian Tumors Figure 5. Proteins in the serum and tumor datasets that are potentially associated with GCR-alpha (A) and SP1 (B) pathways. The proteins marked in blue were found in the serum dataset, those marked in green in both tumor and serum. Unmarked proteins are specific for the ... detect new serum biomarkers for ovarian cancer, we are the first to describe proteomic analysis in both serum and tissue. This approach may lead to detection of serum proteins directly derived from the tumor, which can give new insights in the pathways active in 8 September 2014 | Volume 9 | Issue 9 | e108046 Label-Free LC-MSe in Tissue and Serum of
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Use of cystatin C and serum creatinine for the diagnosis of contrast-induced nephropathy in patients undergoing contrast-enhanced computed tomography at an oncology centre.

... Cockroft-Gault. doi:10.1371/journal.pone.0122877.t003 in serum creatinine on 8.2% and an increase 10% in serum cystatin C on 21.2%. We observed an increase 10% in serum cystatin C in 27.9% of our patients, however they developed no complication indicating the presence of CIN. Conclusions Assessment using serum creatinine and cystatin C concentrations showed ... collected for serum assays immediately before and 72 h after contrast administration, when patients were asked to return for this purpose. Serum concentrations of cystatin C and creatinine were determined by nephelometry and the kinetic Jaffe method, PLOS ONE | DOI:10.1371/journal.pone.0122877 May 11, 2015 3/9 Cystatin C and Serum Creatinine ... two decades [5]. Based on observations of peak serum creatinine concentrations [8][9][10], CIN is classically defined as an increase in the serum creatinine concentration of 0.5 mg/dl or 25% from baseline within 48–72 h after the administration of iodinated contrast medium [11][6][12][13][14]. However, serum creatinine alone is not an accurate marker
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An Investigation of the Effects of Aerobic Exercise on Serum Brain Natriuretic Peptide and C-Reactive Protein in women with Cardiovascular Diseases

... An Investigation of the Effects of Aerobic Exercise on Serum Brain Natriuretic Peptide and C-Reactive Protein in women with Cardiovascular Diseases Najmeh Sheykhiyan1, Eskandar Rahami2*, Mohammadali Ostovan3 1 Sport Physiologist, ... diseases; hence it can be used as a part of treatment. ►Please cite this paper as: Sheykhiyan N, Rahami E, Ostovan M. An Investigation of the Effects of Aerobic Exercise on Serum Brain Natriuretic Peptide and C-Reactive Protein in women with Cardiovascular Diseases. J Cardiothorac Med. 2015; 3(4):379-383. Introduction Coronary artery disease ... weeks of aerobic exercise respectively p˂ . and p˂ . 7 . Sheykhiyan N et al. Discussion The present study examined the effects of eight weeks of aerobic exercise on serum levels of BNP and CRP in females with CAD. We found that BNP and CRP levels diminished after eight weeks of aerobic exercise in females with CAD. The results were in agreement
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Genome-wide scan identifies variant in TNFSF13 associated with serum IgM in a healthy Chinese male population.

... performed a two-stage GWAS in a Chinese male population to explore the genetic influence on serum IgM level. Our study observed the TNFSF13 rs11552708 polymorphism was significantly associated with serum IgM, which suggested that TNFSF13 may be a susceptibility gene affecting serum IgM levels in Chinese male population. Further studies on the association of ... identified SNP (P.0.05). It is suggested that TNFSF13 may be a susceptibility gene affecting serum IgM levels in Chinese male population. Citation: Yang M, Wu Y, Lu Y, Liu C, Sun J, et al. (2012) Genome-Wide Scan Identifies Variant in TNFSF13 Associated with Serum IgM in a Healthy Chinese Male Population. PLoS ONE 7(10): e47990. doi:10.1371/journal.pone.0047990 Editor: ... factors are important in determining serum total immunoglobulin and specific antibody levels in human [6], with genetic heritability for IgM ranging from 45% to 55% [7]. Several studies in a population of common variable immunodeficiency (CVID) patients implied that there might be an association between some gene loci and serum IgM levels [8]. So far, comprehensive
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Localization of microfibrillar-associated protein 4 (MFAP4) in human tissues: clinical evaluation of serum MFAP4 and its association with various cardiovascular conditions.

... studied serum MFAP4 in a clinical cohort to establish a link between serum MFAP4 levels and different stages of atherosclerotic CVD. Lower serum MFAP4 levels were observed in patients with stable atherosclerotic disease compared with CAC-negative individuals. Furthermore, the range of serum MFAP4 levels of CAC-positive patients was between the serum ranges ... cardiomyocytes (Figure 7B). Serum MFAP4 Levels Correlate with Fibulin-1, OPG, and OPN We sought to further delineate the role of MFAP4 by a comparison of serum MFAP4 variation with that of fibulin-1, OPG, and OPN, which are known to be associated with CVD [25,28,30–32]. As indicated in Table 2, we observed a positive correlation between serum MFAP4 and fibulin-1 ... information and biochemical measurements are presented in Table 1. Serum MFAP4 Levels in the Systemic Circulation after AMI Injury Recent work has revealed that MFAP4 is present in serum [19], and because we observed MFAP4 to be highly expressed in VSMCs, we sought to investigate whether serum MFAP4 could reflect ECM turnover in blood vessels in a clinical
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HPLC-DAD-ELSD Combined Pharmacodynamics and Serum Medicinal Chemistry for Quality Assessment of Huangqi Granule.

... | DOI:10.1371/journal.pone.0123176 April 27, 2015 6 / 15 Quality Assessment of Huangqi Granule by HPLC-DAD-ELSD Method Fig 2. Serum pharmacochemistry analysis. A, rat serum before administration; B, blank serum + reference control; and C, 5 min after oral administration of Huangqi granule doi:10.1371/journal.pone.0123176.g002 PLOS ONE ... lipopolysaccharide (LPS) because LPS, which also increases intracellular calcium and H2O2 production in macrophages, also exerts cytotoxic effects on macrophages. Study of serum pharmacochemistry The serum pharmacochemistry of the Huangqi Granule extract was first studied in the present work. As a result, calycosin-7-O-β-D- glucoside, ononin, calycosin, astragaloside ... the paper and its Supporting Information files. To more scientifically and reasonably control the quality of Huangqi Granules, preliminary studies on the pharmacodynamics and serum pharmacochemistry of this medicine were performed. DPPH and MTT experiments showed that water extracts of Huangqi Granules had good antioxidant activity and increased immunity.
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Effects of leucine supplementation and serum withdrawal on branched-chain amino acid pathway gene and protein expression in mouse adipocytes.

... statistically significant difference in LDH activity was noted in adipocytes exposed to serum- withdrawal but not leucine treated cells, suggesting greater cell death with serum withdrawal (p, 0.05). However the difference in the magnitude of the effect was quite small (5.86% in serum- withdrawal vs. 3.09% in control, respectively). Gene selection for qPCR studies ... in growth media (89% DMEM high Glucose, 10% bovine calf serum, antibiotic/ antimycotic/Pen-strep) for 2–3 days to confluency and then incubated for an additional 48 hours to induce growth arrest (Day 0). Growth arrested cells were treated with differentiation media (89% DMEM F12, 10%Fetal Bovine Serum, 1% antibiotic/ antimycotic/Pen-strep, 250 uM 3-isobutyl-1-methylxanthine ... as described above and harvested at Day 0, Day 4 and Day 10 for protein and RNA extraction. Serum withdrawal. Cells were grown in growth, differentiation and maintenance medium as described above. The media were replaced with media deprived of bovine calf serum, and cells were incubated in this media for 18 hours immediately prior to Day 0, Day 4 and
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Evaluation of autologous serum skin test and skin prick test reactivity to house dust mite in patients with chronic spontaneous urticaria.

... than pciMWD. In this study, grade 0 was judged as negative, and grades 1 to 3 were judged as positive. Autologous serum skin test (ASST) Autologous serum (0.05 mL), positive control (10 mg/mL histamine) and negative control (0.3 mg/mL human serum albumin) were separately injected intracutaneously into the flexible forearm with a distance of 5 cm between ... cutaneous reactions against autologous serum were assessed and graded on a scale of 0, 1+, 2+ and 3+ by comparing the size of wheal (mean wheal diameter, MWD) induced by autologus serum, with that induced by 10 mg/mL histamine solution. The degree of the positivity in ASST was classified as follows: grade 0 = the serum- induced mean wheal diameter (siMWD) ... classic standard of positive judgment in which serum- induced weal had a diameter at least 1.5 mm greater than the HSA-induced wheal in our previous study [22]. ASST and ASST were carried out consecutively in one patient on the same day. Detection of serum IgE Total and HDM-specific IgE levels were measured in serum by using the ImmunoCAP 100 instrument
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Effect of lactulose on serum urea, creatinine, calcium and phosphorus in non-azothemic dogs.

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In vitro maintenance of IDE8 cells using two types of bovine serum.

... p.543-546, 2007 Comunicação [Communication] Manutenção in vitro de células IDE8 em dois tipos de soro bovino [In vitro maintenance of IDE8 cells using two types of bovine serum] C.V. Bastos1, M.M.C. Vasconcelos2, M.F.B. Ribeiro2, L.M.F. Passos1* 1Escola de Veterinária - UFMG Caixa Postal 567 30123-970 - Belo Horizonte, MG 2Departamento de Parasitologia ... replaced by the Brazilian SFB one, as no significant differences (P
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Indirect ELISA for the detection of IgG specific to Newcastle disease virus in quail serum.

... 2007 Comunicação [Communication] ELISA indireto para detecção de IgG antivírus da doença de Newcastle em soro de codorna [Indirect ELISA for the detection of IgG specific to Newcastle disease virus in quail serum] D.D. Oliveira1, A.V. Folgueras-Flatschart2, R.B. Flatschart1, J.S. Resende1 J.T. Abreu3, N.R.S. Martins1* 1Escola de Veterinária - UFMG Caixa Postal 567 30123-970
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Serum protein concentration in newborn Holstein calves determined by means of sodium dodecyl sulphate-polyacrylamide gel electrophoresis.

... The highest serum concentration of ceruloplasmin were verified in proteinogram 3, which had the lowest serum level of protein with MW 58,000D. It was verified α1-antitrypsin only in proteinogram 2, which had no proteins with MW of 42,000 D and 37,000D. The highest serum concentrations of IgA and protein with MW 58,000 D, and the lowest serum levels ... verified in proteinogram 3. Measurement of serum protein concentrations by SDS-PAGE may be useful in monitoring the occurrence of hypogammaglobulinemia and the neonatal disease in calves. Keywords: calf, proteinogram, electrophoresis, SDS-PAGE REFERÊNCIAS BIBLIOGRÁFICAS ABEL FRANCISCO, S.F.; QUIGLEY, J.D. Serum immunoglobulin concentrations after ... McCLENAHAN, D. et al. Serum protein concentrations in calves with experimentally induced pneumonic pasteurellosis. Arq. Bras. Med. Vet. Zootec., v.55, p.383-387, 2003. GORDON, A.H. Electrophoresis of proteins in polyacrylamide and starch gels. New York: Elsever Science Publishers, 1975. 213p. KEAY, G.; DOXEY, D.L. Species characteristics of serum proteins
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Serum levels of hepatic enzyme function in clinically healthy broiler chickens.

... samples of serum of broiler chickens in industrial system, clinically healthy, starting from the seventh day of life, until the slaughter (42 days) in weekly intervals were determined. Significant variations were not observed in the analyses in relation to the age of the birds for none of the appraised enzymes. Keywords: broiler chicken, serum enzymes, ... Zootec., v.58, n.4, p.675-677, 2006 Comunicação [Communication] Níveis séricos de enzimas de função hepática em frangos de corte de criação industrial clinicamente saudáveis [Serum levels of hepatic enzyme function in clinically healthy broiler chickens] A. Borsa, A. Kohayagawa, L.P. Boretti, M.E. Saito, K. Kuibida Faculdade de Medicina Veterinária
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Hematological profile and electrophoretic evaluation of serum proteins of dogs with canine distemper.

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Hemogram, serum biochemistry and hepatic histologic features in cattle after administration of citrus pulp.

... consumption. However, there was an increase of serum phosphorus and reduction of serum calcium (p≤0.05), without hypercalcemia, after consumption of citrus pulp diet. There was also an increase in serum alkaline phosphatase (p≤0.05), probably induced by bone isoenzyme. Keywords: cattle, citrus pulp, hemogram, serum biochemistry, hepatic histology REFERÊNCIAS ... beef cattle. 6.ed. Washington: NRC, 1984. 90p. ROUSSEL, A.J.; WHITNEY, M.S.; COLE, D.J. Interpreting a bovine serum chemistry profile: part1. Vet. Med., v.92, p.553-558, 1997a. ROUSSEL, A.J.; WHITNEY, M.S.; COLE, D.J. Interpreting a bovine serum chemistry profile: part 2. Vet. Med., v.92, p.559-566, 1997b. SAMPAIO, I.B.M. Estatística aplicada à experimentação ... n.3, p.418-422, 2005 Comunicação [Communication] Hemograma, bioquímica sérica e histologia da biópsia hepática de bovinos após administração de polpa cítrica [Hemogram, serum biochemistry and hepatic histologic features in cattle after administration of citrus pulp] N.J.F. Oliveira, M.M. Melo, L.A. Lago, E.F. Nascimento Departamento de Clínica
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Serum IgM as an indicator of intrauterine infection in Colombian newborns

... asymptomatic newborns Table 3. Comparison of selected immunologic parameters in newborns with normal and elevated serum IgM concentrations. Normal serum IgM (mean Variable zt stmdardemr of the mean; ” - 75) Serum IgM (mg%) Serum IgA (mg%) Serum IgG (mg%) Serum C3 (mg%) Lymphocyte blastogenesisb with phytohemagglutinin Lymphocyte blastogenesish with pokeweed ... a fluorescein-conjugated anti-human IgM antiserum were used for each test (Microbiological Research Corporation). Each infant serum was tested over a series of two-fold dilutions and an end-point was determined. Each test included a negative control serum as well as one strong and one weak positive control serum. The minimum dilutions accepted as positive were ... was found to provide a rapid and useful screening method for detecting elevated serum IgM in newborns. The results were available within 2 hours of receipt of the serum sample, and the test detected nearly all of the newborns with McMurray et al. l SERUM IgM AND INTRAUTERINE serum IgM concentrations greater than 40 mg per cent-including every child
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