Neutrophil Elastase

Relationship between Neutrophil-to-Lymphocyte Ratio and Prognosis in Patients with Deep Neck Space Infection

... Cassatella, C. Costantini, S. Jaillon. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011;11:519-531. 5. B. Amulic, C. Cazalet, GL. Hayes, et al. Neutrophil function: from mechanisms to disease. Ann Rev Immunol 2012;30:459-489. 6. Nunez J, Nunez E, Bodi V, et al. Usefulness of the neutrophil to lymphocyte ratio ... göstermiştir. Conclusion: This study showed that the neutrophil- tolymphocyte ratio can be used as a cheap, easily obtained and predictive prognostic factor in patients with deep neck infections. Anahtar kelimeler: Derin boyun enfeksiyonu, komplikasyon, nötrofil/lenfosit oranı Key words: Deep neck space infection, complication, neutrophil- to-lymphocyte ratio. Kulak ... any complication during follow-up and treatment duration. The mean neutrophil- to-lymphocyte ratio in patients with complications was significantly higher than the patients without any complications (p
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Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients.

... neutrophil count and anion gap were selected as independent variables determining serum NGAL levels (Table 3, Fig 1A–1C). Next, we investigated clinical implication of the above findings (Fig 1 and S4 Table). Blood neutrophil count showed strong correlation with WBC count (r = 0.92, P
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Burn injury reduces neutrophil directional migration speed in microfluidic devices.

... Volume 5 | Issue 7 | e11921 Neutrophil Chemotaxis Assay Figure 6. Correlations between neutrophil motility and neutrophil counts in burn patients. a. No significant correlation was found between neutrophil motility and the absolute neutrophil count (R2 = 0.2). b. Also, there was no significant correlation between average neutrophil motility and percentage ... the moving neutrophils. Device validation Most of the neutrophils maintain constant speed toward fMLP within the channels for at least the first 10 minutes (Fig. 3 and Movie S1). Interestingly, a few neutrophils moved faster for the PLoS ONE | 4 July 2010 | Volume 5 | Issue 7 | e11921 Neutrophil Chemotaxis Assay Figure 3. Neutrophil ... between neutrophil migration speed and temperature (R2 = 0.2) (Fig. 5b), absolute neutrophil count (R2 = 0.23), or the percentage of band cells in the neutrophil population (R2 = 0.01) (Fig. 6). Neutrophil motility was most depressed between 72 and 120 hours after injury (Fig. 7), with an average migration speed of 862 mm/min. After this time frame, neutrophils
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A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis.

... decay Fixed 1000 0 CFU 6 kNB Basal neutrophil natural Fixed 0.1 0 Hour-1 7 kNK Killer neutrophil decay Fitted 0.0330 0.0275 Hour-1 8 kNM Migratory neutrophil decay Fitted 0.1244 0.1936 Hour-1 9 kNK=M Migratory-Killer neutrophil decay Fitted 0.1176 0.1772 Hour-1 10 kNM NK IL8 IL-8 induced migratory neutrophil to neutrophil migratory-killer ... trapped 0.0 0.0 unitless 15 CfMLP fMLP 0.0 0.0 nM 16 Celas Neutrophil elastase / α1-PI complex 0.0 0.0 ng/ml 17 WBC Total white blood cells 4.4 5.06 103 cells/μl doi:10.1371/journal.pcbi.1004314.t001 growth phase. Levels of neutrophil elastase / α1-PI complex in the blood, indicative of the killing and damage causing function of activated neutrophils, peaks around 15 ... rate of the killer neutrophils, kNK (direction of influence shown in Fig (6D)). The decay rate of the killer neutrophil controls the rate at which killer neutrophils are removed from the system, and the faster these neutrophils are removed, the lesser the damage. The next important term is the direct damaging effect of the killer neutrophils and this
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Paraquat-induced reactive oxygen species inhibit neutrophil apoptosis via a p38 MAPK/NF-κB-IL-6/TNF-α positive-feedback circuit.

... complex modulation of neutrophil apoptosis [4,5]. Under normal circumstances, rapid apoptosis is a neutrophilic characteristic. The average life span of neutrophil is 8-20 h in circulation [6]. Control of neutrophil apoptosis is essential to rapidly resolve inflammatory reactions [7]. Recent studies have shown that apoptosis contributes to ALI pathogenesis, and neutrophil ... final viability of isolated neutrophils was assessed by trypan blue dye (routinely . 98%). Neutrophils were then resuspended at a density of 1.66105/ ml in Dulbecco’s phosphate-buffered saline (DPBS) with Ca2+, Mg2+, 1 g/L glucose, and 4 mM sodium bicarbonate. Treatment To detect the effect of PQ on neutrophil survival, neutrophils were stimulated ... certain concentrations of PQ ($5 mM) could prolong neutrophil survival in a concentration-independent manner. The highest percentage of delay was 6 h after treatment in each group. Hence, we used 5 mM PQ for 6 h in the next experiments. Analysis of neutrophil apoptosis PQ-induced ROS generation regulates neutrophil apoptosis Neutrophil apoptosis was measured with
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Severe exercise and exercise training exert opposite effects on human neutrophil apoptosis via altering the redox status.

... the neutrophil redox status toward a relatively oxidative state. Reduction of neutrophil DYm in vitro To verify the role of neutrophil DYm reduction in neutrophil apoptosis and ROS generation, neutrophils isolated from 6 additional sedentary subjects (age 2161 yr, body weight 6762 kg, height 17361 cm, resting heart rate 7265 bpm) were recruited for neutrophil ... oxidase (an enzyme complex which produces ROS) increase neutrophil lifespan as compared with neutrophils from healthy subjects [8,9]. Third, neutrophil glutathiPLoS ONE | 1 September 2011 | Volume 6 | Issue 9 | e24385 Exercise Affects Neutrophil Apoptosis and ROS stimulate the neutrophil ROS release [20–22], while other studies using ... accumulation, and limits neutrophil lifespan [10]. Although mitochondrial is generally considered a major source of ROS, whether mitochondrial ROS (mtROS) participate in neutrophil apoptosis is unclear. Neutrophil mitochondria hardly participate in energy production but usually involve in apoptosis regulation instead [11]. Apoptotic neutrophils are functionally compromised
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The Predictivity of Neutrophil Gelatinase Associated Lipocaline in the Development of Radiocontrast-Induced Nephropathy in the Intensive Care Unit Patients

... Predictivity of Neutrophil Gelatinase Associated Lipocaline in the Development of Radiocontrast-Induced Nephropathy in the Intensive Care Unit Patients Yoğun Bakım Hastalarında Radyokontrast Nefropati Gelişiminde Nötrofil Jelatinazla İlişkili Lipokalin Prediktivitesi ABSTRACT OBJECTIVE: The aim of this study is to investigate the predictive value of neutrophil ... 3-5 days and the levels return to normal within 1-3 weeks. During recent years, new biomarkers have been studied for the early diagnosis of acute kidney injury (AKI) (3,4,5). Neutrophil gelatinase associated lipocalcin (NGAL) is a member of the lipocaline superfamily with a molecular weight of 25 kd. It is a tubular protein in the kidneys and found ... Nephrology (3rd ed). Philadelphia: Elsevier, 2007; 779-780 5. Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A; NGAL Meta-analysis investigator group: Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: A systematic review and meta-analysis. Am J Kidney Dis 2009; 54(6): 1012-1024 6.
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Neutrophil mobilization by surface-glycan altered Th17-skewing bacteria mitigates periodontal pathogen persistence and associated alveolar bone loss.

... coordinating early neutrophil PLOS ONE | 6 September 2014 | Volume 9 | Issue 9 | e108030 Neutrophils Block Periodontal Pathogen Persistence recruitment into local sites of infection [18]. IL-17, in addition to orchestrating the chemokine cascades required for neutrophil mobilization, may also augment the killing activity of neutrophils ... September 2014 | Volume 9 | Issue 9 | e108030 Neutrophils Block Periodontal Pathogen Persistence Figure 4. Lymphocyte /neutrophil infiltration in gingival tissues of mice primed with ED1 and infected with P. gingivalis. Immunohistochemical staining for total CD45 positive inflammatory cells (A) and neutrophils (B) in gingival tissue. All images are ... type-5 and 8 [13,14]. In the gingival sulcus, neutrophils and Th17 responses play protective roles by clearing P. gingivalis. Neutrophils are sentinel cells of the innate immune system that keep the gingival surface free of pathogenic bacteria by forming a protective ‘wall’ [15,16]. At the same time, a heightened neutrophil infiltration could be detrimental
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TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis.

... of TLRs. Neutrophil depletion in WT mice leads to amelioration of AKI after sepsis The decreased migration of neutrophils to the kidneys of the knockout mice after sepsis led us to hypothesize that neutrophils are also the main immune cells involved in the pathogenesis of AKI secondary to sepsis. Based on this hypothesis, we depleted neutrophils. ... MyD882/2 mice had lower neutrophil infiltration in the kidneys. Depletion of neutrophils in the WT mice led to protection of renal function and less inflammation in the kidneys of these mice. Innate immunity participates in polymicrobial sepsis-induced AKI, mainly through the MyD88 pathway, by leading to an increased migration of neutrophils to the kidney, ... and e). These results suggested that an absence or even decrease in neutrophils confers protection against sepsisinduced AKI. Effect of TLR2, TLR4 and MyD88 deficiency on neutrophil migration to the kidney after CLP To study whether the absence of TLRs and MyD88 leads to reduced neutrophil migration to the kidney after CLP, we first analyzed the
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Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 MAPK signalling and Mac-1 activation.

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Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors.

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