Antioxidant Drugs

Docking Studies on Anticancer Drugs for Breast Cancer Using Hex

... estrogen receptor and the commercially available drugs against breast cancer. The receptor was docked to the above said drugs and the energy value obtained as follows Tamoxifen (-49.0), Raloxifene (-158.0), Toremifene (-108.0) using the HEX docking software. Depending on the energy values we have chosen the best two drugs they are Raloxifene and Toremifene. ... designing. In the present work we have taken the receptor Human estrogen and identified the drugs that were used against Breast Cancer. When the receptor (2IOK) was docked with the drugs the energy value obtained was; Raloxifene (-158.37), Toremifene( -108.0). When the modified drugs were docked against the same receptor the energy value obtained was Raloxifene ... software. Raloxifene Analog 7 and Toremifene analog 6 were detected with significant energy values and probable lead molecules. The Modified drugs was sketched using Chemsketch were found to be better than the conventional drugs available. Further from this work we can improve the steric compatibility and then ADME/T properties of the Analogs can be analyzed
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iGPCR-drug: a web server for predicting interaction between GPCRs and drugs in cellular networking.

... many diseases such as cancer, diabetes, neurodegenerative, inflammatory and respiratory disorders, GPCRs are among the most frequent targets of therapeutic drugs [4]. Over half of all prescription drugs currently on the market are actually acting by targeting GPCRs PLOS ONE | 1 August 2013 | Volume 8 | Issue 8 | e72234 Predict GPCR ... a GPCR (protein) and a drug, a combination of the following two approaches were adopted to represent the GPCR{drug pair samples. (a) Representing drugs with 2D molecular fingerprints. Although the number of drugs is extremely large, most are very difficult to crystallize and most of them will not dissolve in normal solvents. Although a series of recent ... structures for most GPCRs are still unknown. To overcome the situation, a sequence-based classifier, called ‘‘iGPCR-drug’’, was developed to predict the interactions between GPCRs and drugs in cellular networking. In the predictor, the drug compound is formulated by a 2D (dimensional) fingerprint via a 256D vector, GPCR by the PseAAC (pseudo amino acid composition) generated
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SWEETLEAD: an in silico database of approved drugs, regulated chemicals, and herbal isolates for computer-aided drug discovery.

... where over 31% of non -drugs have less than 2 rotatable bonds as compared to 13% for approved drugs. Additionally, 93% of the non-approved compounds pass Lipinski’s Rule of 5 with only 1 violation, identical to the 93% mark for approved drugs, which indicates their drug likeness according to that metric. Overall, both the drugs and non -drugs in the SWEETLEAD ... are approved drugs in at least one region and 1427 are FDA approved drugs. 217 of these compounds are scheduled drugs in the United States, and 1625 of the compounds derive from traditional medicinal herbs. Some compounds can be multiply classified, such as methamphetamine and codeine which are both approved therapeutics and scheduled drugs. Reflecting the ... accurate chemical structures of approved drugs. Using an automated tool, we queried several free, public, and well-used chemical databases for reported structures of approved drugs and employed these structures in a consensus building scheme to identify the true structure for every approved drug. In addition to approved drugs, we include the structures of
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... medication includes liquid lipophilic drugs and drug suspensions or solutions of solid water insoluble drugs in suitable non-volatile solvent systems. Liquisolid systems refers to powdered forms of liquid medications formulated by converting liquid lipophilic drugs, or drug suspensions or solutions of water insoluble solid drugs in suitable non-volatile solvent ... major challenges in oral delivery of new drug substances. Orally administered drugs on the Model list of Essential Medicines of the World Health Organization (WHO) are assigned BCS classifications on the basis of data available in the public domain 2. Of the 130 orally administered drugs on the WHO list, could be classified with certainty. 84% of these belong ... reducing the particle size, the increased surface area improves the dissolution properties of the drug. Micronization of drugs is done by milling techniques using jet mill, rotor stator colloid mills etc. Micronization is not suitable for drugs having a high dose number because it does not change the saturation solubility of the drug 46. Nanosuspension is
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Study of the effect of surfactants on extraction and determination of polyphenolic compounds and antioxidant capacity of fruits extracts.

... oxidized themselves, so antioxidants are often reducing agents. Plants and animals maintain complex systems of multiple types of antioxidants, such as glutathione, vitamin C, vitamin A, vitamin E, and polyphenolic compounds (as secondary metabolites in plants) as well as enzymes such as catalase, superoxide dismutase and various peroxidases. Insufficient levels of antioxidants, ... consequence of disease. Antioxidants are widely used in dietary supplements and have been investigated for the prevention of diseases such as cancer, coronary heart disease. Antioxidants are classified into two broad divisions, depending on whether they are soluble in water (hydrophilic) or in lipids (hydrophobic). In general, water-soluble antioxidants react ... cell cytosol and the blood plasma, while lipidsoluble antioxidants protect cell membranes from lipid peroxidation. These compounds may be synthesized in the body or obtained from the diet. As mentioned above plant products have great potential of antioxidant activity due to contain of secondary antioxidant polyphenolic compounds. Extraction of these
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Composition and antioxidant properties of fresh and frozen stored blackthorn fruits (Prunus spinosa L.)

... presented in the blackthorn fruits are: K, Ca, P, Mg, Na, B and Al. Table 2 presents the results of the analyses of antioxidant compounds contents and antioxidant activity in fresh and frozen blackthorn fruits. Table 2. Content of antioxidants and antioxidant activity in blackthorn fruits (Prunus spinosa L.) Component Fresh material Frozen material mg/100 ... influence on nutritive and antioxidant compounds of blackthorn fruits. It may be therefore observed that several months of frozen storage is a good way to make them available for fruit processing and for the consumers, also the off-season. Key words: blackthorn (Prunus spinosa), frozen storage, chemical composition, antioxidants, antioxidant activity INTRODUCTION At ... significant effect of frozen storage of high bush variety of blueberries on their antioxidant activity. Slightly lower values of total antioxidant activity of blackthorn fruits were received by Dragović-Uzelac 369 Sikora E., Bieniek M.I., Borczak B., 2013. Composition and antioxidant properties of fresh and frozen stored blackthorn fruits (Prunus spinosa
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Optimization of the Ocimum basilicum L. extraction process regarding the antioxidant activity

... main antioxidant agent. In a past few years, much attention has been paid to the extraction of antioxidants and the creation of antioxidant supplements from different natural sources (herbs, fruits and vegetables). This attention increases since some of synthetic antioxidants used in the food and other industries have been reported to be toxic. Natural antioxidants ... and extraction temperature on the extraction of antioxidant compounds and on the antioxidant activity of O. basilicum extracts. Three responses in the form of different components and antioxidant activity of the extracts were evaluated: total phenols content (TP), Y1, total flavonoids content (TF), Y2, and antioxidant activity (IC50), Y3. Nineteen runs, ... plants, as carriers of antioxidant compounds and antioxidant activity, could be obtained by different methods, by using different solvents and at different process conditions (temperature, time, pressure, etc.). Extraction with organic solvents offers good recovery of polyphenols, which is related to the preparation of extracts with high antioxidant activity.
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Efficacy and safety of oral antidiabetic drugs in comparison to insulin in treating gestational diabetes mellitus: a meta-analysis.

... Efficacy and Safety of Oral Antidiabetic Drugs in Comparison to Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis Nalinee Poolsup1, Naeti Suksomboon2*, Muhammad Amin2 1 Department of Pharmacy, Faculty ... Nakhon-Pathom, Thailand, 2 Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand Abstract Objective: To assess the efficacy and safety of oral antidiabetic drugs (OADs) in gestational diabetes mellitus (GDM) in comparison to insulin. Methods: A meta-analysis of randomized controlled trials was conducted. The efficacy and safety of ... insulin and a better choice than glyburide especially those with mild form of disease. Citation: Poolsup N, Suksomboon N, Amin M (2014) Efficacy and Safety of Oral Antidiabetic Drugs in Comparison to Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis. PLoS ONE 9(10): e109985. doi:10.1371/journal.pone.0109985 Editor: Marta L. Hribal, University
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How Antiparasitic Drugs Work-And Sometimes Stop Working!

... RESEARCH MATTERS How Antiparasitic Drugs Work—And Sometimes Stop Working! David Horn* Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom * a11111 OPEN ACCESS Citation: Horn D (2016) How Antiparasitic Drugs Work—And Sometimes Stop Working! PLoS Pathog 12(5): ... antiparasitic drugs are constantly threatened by obsolescence in the “arms race” between us and the parasites. In the hope of helping to gain the upper hand in this race, we adapted a genetic screening approach that allows us to survey every parasite gene for roles in drug action and drug resistance. This revealed >50 new genes linked to drugs in clinical ... screening approach that allows us to survey every parasite gene for roles in drug action and drug resistance. This revealed >50 new genes linked to drugs in clinical use. The drugs nifurtimox and eflornithine, for example, are widely used as a combination therapy. PLOS Pathogens | DOI:10.1371/journal.ppat.1005430 May 5, 2016 1/3 We confirmed that
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Optimization of extraction parameters on the antioxidant properties of banana waste

... Prakash, 2011). Banana peel contains potent antioxidant compounds. Vitamin A, vitamin C, and carotenoids are the most abundant antioxidants in banana pulp as well as in banana peel (Arora et al., 2008; Pereira and Maraschin, 2015; Tsamo et al., 2015; US Department..., 2014). Banana peels are also known to have higher antioxidant activity (AA) than the pulp ... our knowledge, the studies on optimum extraction conditions of antioxidants from natural sources are still scarce. Therefore, this study aimed to establish a standard antioxidant extraction method by investigating the influence of extraction parameters on total phenolic content (TPC) and antioxidant activity (AA) of the peels of mature and green banana ... parameters on the antioxidant properties of banana waste. Acta Sci. Pol. Technol. Aliment., 15(1), 65–78. DOI: 10.17306/J.AFS.2016.1.7 and lycopene in Portuguese wild edible mushrooms and their antioxidant activities. Food Chem., 103, 413–419. Brand-Williams, W., Cuvelier, M. E., Berset, C. L. W. T. (1995). Use of a free radical method to evaluate antioxidant
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An Ultrastructural Study of the Antioxidant Effects of Vitamin E and Fennel Extract on Zona Pellucida Cell Changes of Rat Ovaries under Non-Ionizing 50Hz Electromagnetic Fields

... Open Access Crescent Journal of Medical and Biological Sciences Vol. 2, No. 2, Spring 2015, 37-41 eISSN: 2148-9696 Original Article An Ultrastructural Study of the Antioxidant Effects of Vitamin E and Fennel Extract on Zona Pellucida Cell Changes of Rat Ovaries under Non-Ionizing 50Hz Electromagnetic Fields Ali Asghari1, Azadeh Montaseri2, ... react with unsaturated fatty acids in cell membranes, resulting in the lipid peroxidation process (10). Vitamin E is a fat-soluble vitamin. This vitamin, like vitamin C, has antioxidant properties and destroys the damaging effects of chemicals on the body’s tissues. Vitamin E was isolated from wheat germ and was called alpha-Tocopherol. This name is ... changes were less observed in the groups that used vitamin E and fennel extract (12,13). Conclusion Given the irreversible changes caused in ovary cells due to EMFs and the role of antioxidants, such as vitamin E and fennel extract, in the protection of the zona pellucida, it was concluded that protecting zona pellucida resulted in the protection of oocytes,
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SERPINA3K plays antioxidant roles in cultured pterygial epithelial cells through regulating ROS system.

... the antioxidant activity of SERPINA3K in the corneal epithelium [13]. Since we mainly focused on the antioxidant role of SERPINA3K in pterygium, it is necessary to make a further comparison of the antioxidant activities of SERPINA3K between the pterygium, conjunctiva and corneas with same range and stages of age to better understand and evaluate the antioxidant ... (LRP6). We provided novel evidence that SERPINA3K had inhibitory effects on pterygium and SERPINA3K played antioxidant role via regulating the ROS system and antioxidants. Citation: Zhu C, Pan F, Ge L, Zhou J, Chen L, et al. (2014) SERPINA3K Plays Antioxidant Roles in Cultured Pterygial Epithelial Cells through Regulating ROS System. PLoS ONE 9(10): e108859. ... Center, Oklahoma City, Oklahoma, United States of America Abstract We recently demonstrated that SERPINA3K, a serine proteinase inhibitor, has antioxidant activity in the cornea. Here we investigated the antioxidant effects of SERPINA3K on the pterygial, which is partially caused by oxidative stress in pathogenesis. The head part of primary pterygial
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Sodium montmorillonite/amine-containing drugs complexes: new insights on intercalated drugs arrangement into layered carrier material.

... slow release of protonable drugs. Herein, we describe the intercalation of several amine-containing drugs with Na-MMT so we can derive a better understanding of how these drugs molecules interact with and distribute throughout the Na-MMT interlayer space. Therefore, for this purpose nine sodium montmorillonite/ amine-containing drugs complexes (Na-MMT/drug) ... physicochemical properties of the drugs molecules in combination with different experimental conditions were assessed to determine how these factors influenced experimental outcomes (e.g. increase of the interlayer spacing versus drugs arrangement and orientation). We also performed a molecular modeling study of these amine-containing drugs associated with different ... study we analyzed the intercalation of amine-containing drugs in Na-MMT using experimental assays and molecular dynamics simulations. This approach allowed us to correlate the molecular orientation of amine-containing drugs with the amount of basal spacing found in Na-MMT. Amine-Containing Drugs Intercalation into Na-MMT Characterization of the
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New Inhibitors of the DENV-NS5 RdRp from Carpolepis laurifolia as Potential Antiviral Drugs for Dengue Treatment

... SHORT REPORT Rec. Nat. Prod. 8:3 (2014) 286-289 New Inhibitors of the DENV-NS5 RdRp from Carpolepis laurifolia as Potential Antiviral Drugs for Dengue Treatment Paul Coulerie1, Alexandre Maciuk2, Cécilia Eydoux3, Edouard Hnawia1, Nicolas Lebouvier1, Bruno Figadère2, Jean-Claude Guillemot3 and Mohammed Nour *1 1Laboratoire
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Oxidative stress and the antioxidant enzyme system in the developing brain

... oxygen species, Antioxidants, Brain injuries, Premature infant Introduction Premature infants are especially vulnerable to reactive oxygen species (ROS)-induced injury1) because of their insufficient ability to synthesize antioxidant enzymes and the resulting deficiency of antioxidant enzymes. The imbalance between ROS production and antioxidant defense ... is secreted predominantly in the pineal gland and has potent antioxidant and anti-inflammatory activities. Melatonin acts as a direct antioxidant by scavenging free radicals, including OH•, O2•-, H2O2, and peroxynitrite. Melatonin acts as an indirect antioxidant by increasing the levels of antioxidant enzymes such as GPx, glutathione reductase, SOD, ... production and the antioxidant enzyme system. However, if this balance breaks down, ROS oxidize lipids, proteins, and polysac­ charides and can damage DNA and RNA4,5). Aerobic organisms have developed antioxidant defenses. Superoxide dismutase (SOD); catalase; glutathione peroxidase (GPx); vitamins A, C, and E; and glutathione are com­mon antioxidants6).
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The prescribing of psychotropic drugs in mental health services in Trinidad

... drug. Antidepressant drugs were the class of psychotropic drugs most prescribed (79 of 132 patients, or 59.8%), followed by antipsychotic drugs (67 of 132 patients, 50.8%). Benzodiazepines were prescribed to 9.1% of the patients (12 of 132), while the anticholinergic drugs represented 15.2% (20 of 132). Among the antidepressant drugs, tricyclic antidepressants ... using two or more drugs, either more than one psychotropic or a combination of psychotropic(s) and nonpsychotropic(s). Of these 83 patients, 63 of them were using either two or three drugs concomitantly, 17 of them were using four or five drugs, and 3 of them were using six or more drugs. Out of this group of patients using two or more drugs concomitantly, ... using nonpsychotropic drugs. Of these 51, 41 of them were using drugs prescribed by another physician, that is, not the psychiatrist at the clinic. In addition, 15 of the 51 were self-medicating, according to their self-reporting. In terms of the groups of nonpsychotropic drugs used concomitantly, 209 TABLE 2. Use of psychotropic drugs, by ethnicity,
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Selection of two governments from the region of the Americas to the WHO management advisory committee of the action program on essential drugs

... ACTION CSP23/20 (Eng.) 24 July 1990 ORIGINAL: ENGLISH REGION OF THE AMERICAS TO PROGRAM ON ESSENTIAL DRUGS The objective of the WHO Action Program on Essential Drugs (DAP), established in 1981, is to support Member States in ensuring the regular supply of essential drugs of acceptable quality and low cost to help achieve the goal of Health for All by the Year ... Management responsibilities Action Programme Director-General the ON ESSENTIAL Advisory (Eng.) DRUGS Committee Advisory Committee (MAC) represents the interests of WHO's external partners collaborating with WHO in on Essential Drugs. It acts as an advisory body to of WHO, making recommendations on matters related to the policy, strategy, finance, management, monitoring the WHO's Action Programme on Essential Drugs (DAP). and evaluation of Functions - ... and Management. The Division also includes other Programs concerned with medicinal products: Pharmaceuticals, Biologicals, Traditional Medicine, and Psychotropic and Narcotic Drugs. The integration of all drug-related programs is intended to provide for greater balance in the emphasis laid upon the various elements of WHO's Revised Drug Strategy. At
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Control of drugs in a university hospital surgical ward

... prescribed, requisitioned, issued, and administered to patients at the women’s surgical ward of the Valle University Hospital, 14 May-14 June 1981. Value of drugs (in US) Drugsprescribed Drugsrequisitioned Drugsissued Drugs administeredto patients %of pES~lZS~ 1,091&i 1.303.07 927.17 100 119 84 659.92 60 Quantity prescribed: The quantity prescribed by the doctor, ... regarding administration of drugs to patients at the women’s surgical ward of the Valle University Hospital, 14 May-14 June, 1981. Drugs authorized Use of drugs Vallle UJSS) Administeredto ward patients Not administeredto ward patients Total % of total WlW 659.92 60 431.52 40 1,091.44 100 Table 5. The value (in US$) of the drugs prescribed, requisitioned, ... patients by their doctors. Pe’rez et al. 253 rn CONTROL OF DRUGS IN A HOSPITAL SETTING Table 2. Initial survey: Compliance with physician’s instructions regarding administration of drugs to patients at the women’s surgical ward of the Valle University Hospital, May 1980. Drugs authorized Use of drugs ValW WSS) Administered to ward patients Not administered
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Policies for the production and marketing of essential drugs: discussion guide

... September 1983 ORIGINAL: ENGLISH POLICIES FOR THE PRODUCTION AND MARKETING OF ESSENTIAL DRUGS Discussion Guide 1. What mechanisms can be employed by Member Governments, private industry and international organizations to support the objective of making essential drugs available to the majority of the population at an affordable price? 2. Under what ... a desirable alternative? 3. How can the financial, logistical, and cultural obstacles effective distribution of essential drugs best be overcome? 4. How can Member Countries evaluate the impact of policies and programs related to essential drugs? 5. What short- and long-term activities are open to PAHO, Member Governments, and private industry to improve
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Policies for the production and marketing of essential drugs: program

... Technical avf-IN X 6··SAN~a: Discussions INDEXED Washington, D.C. September-October 1983 Provisional Agenda Item 18 CD29/DT/3 (Eng.) 20 September 1983 ORIGINAL: ENGLISH POLICIES FOR THE PRODUCTION AND MARKETING OF ESSENTIAL DRUGS Program 30 September 1983 9:00 a.m. FIRST PLENARY SESSION Opening--Moderator of the Technical Discussions 9:15 a.m. Keynote Address--Dr. Gary Gereffi 10:00 a.m. Description
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Report of the technical discussions on the impact of drugs on health costs: national and international problems

... need. Basic Drugs _2/ The participants recognized the importance of drugs in the protection and restoration of health. Special emphasis should be given to essential or basic drugs which are those most needed for the health care of the majority of the population. These drugs must be readily available to all. The main purposes of using a list of basic drugs ... and other forms of promotion, including prohibition of promotion to the public of certain categories of drugs or of drugs for certain diseases; - lists of basic drugs and/or drugs to be provided plan or through reimbursement schemes; - prices of drugs; - import - regulatory and export; action through the health -. and and legal penalties. RECOMMENDATIONS The_prking Group ... the use of "mood" drugs, as well as "fads" or poorly founded beliefs in the efficacy of such d_ug products as tonics and high-potency vitamins. Also_ physicians tend to prescribe unnecessary drugs. One of the serious problems to be addressed by a national drug policy is the disparity between the frequently inadequate provision of drugs essential to
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Evaluation of new drugs in the treatment of Rickettsial diseases

... selección de los trabajos in toto o compendiados. sólo los autores son solidiwios de las vertidas. a menos que conste espl&itamente lo contrario ophiones Enero de 1949 No. OF NEW DRUGS IN THE TREATMENT RICKIXTTSIAL DISEASES* By J. E. i%ADEL, 1 OF M.D. Department of Virus and Rickettsial Diseases, Army Medical Department, Research und Graduate Xchool, ... treating certain bacteria1 complications which develop in rickettsial infections. We shall return later in the talk to a discussion of the newer antibiotics. A large number of drugs were tested for their activity in the rickettsioses during and immediately prior to the war years. These fe11into severa1 broad groups including the sulfonamides, the acridines
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Response to short-course chemotherapy of patients with initial resistance to antituberculosis drugs

... of: Onemonth Twomonths (2.9) (8.4) ; a Amongthe patientswith infectionsrenderedinactive. TABLE6. Impact of initfal resistanceto one or more of the drugs used upon the effectivenessof treatment. Initialsensitivity of infections Sensitive Resistant to oneor moredrugs Total Successful treatments (infectionrendered inactive,no relapse) Treatment failures Total Relapses No. (%I No. (%I No. (%) No. 1,696 (95.3) 11 (0.6) 74 (4.1) 1,781 (100.0) 163 1,859 (86.3) (94.3) 16 27 (8.4) (1.4) IO 84 (5.3) (4.3) 189 (100.0) 1,970 (100.0) overvalued; ... the beginning of treatment-in terms of the failures and relapses occurring among patients with sensitive and resistant strains; 0 to evaluate the respective roles of two major drugs, streptomycin and isoniazid, in the genesis of failures and relapses; and . to determine whether or not there were differences in the responsesof patients with primary resistance ... short-course(SC)treatmentregimensprovided fur the six groups 01study subjects. The numbers after the letters “SC” indicatethe year when each regimen was first instituted among the study subjects. The drugs employedare indicatedas follows: S = streptomycin: H = isoniazid; R = rilampin; and 2 = pyrazinamide. Identifyingcode SC-78 SC-80 SC-81 SC-82 s 2 .,$ PI % a : 3 176 SC-84 Regimen9 2SHW/4S2H2R2b 2SHRZ/4S2H& 2SHRZ/4S2H2 2SHRZ/5S2H2Z2 i
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Prevalence of the improper use of alcohol, tobacco, and drugs in the Ecuadorian population

... psychotropic drugs (for example, 16% reported using tranquilizers at least once). The percentages using the same drugs illegally, without prescription, were lower (for example, 4% in the case of tranquilizers), and the percentages reporting use of outlawed drugs were also small (the respective percentages reporting use of marijuana, inhalants, native plant drugs, ... respectively), and the percentages acknowledging use of outlawed drugs (marijuana-4%, inhalants-2%, native plant drugs- l%, cocaine-l%, and cocaine base-l%) were also low. The criteria used for estimating addiction to the various substances were exclusively quantitative. That is, a person using psychotropic drugs daily was considered addicted, as was a person who ... substance and form of consumption. The results showed that the drugs used by the most survey subjects at least once in their lives (that is, with the highest lifetime user prevalences) were alcohol (used by 75%) and tobacco (used by 54%). Far smaller percentages indicated they had used psychotropic drugs. In all, the percentages acknowledging use of medically
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Fixed combinations of antibiotic drugs used in Central America

... F IXED COMBINATIONS OF ANTIBIOTIC DRUGS USED IN CENTRAL AMERICA1 Fededco Guerrero-M&ox2 I NTRODUCTION Antibiotics are among the drugs most prescribed by physicians in medical practice. It is also true, however, that increasing bacterial resistance to many of these drugs has been observed in recent years, a phenomenon that ... worthwhile drugs. The authors therefore suggest that manufacturers be required to place in the Diccionario all information about each of their antibiotics that is contained in the Physicians’ Desk Reference. They also recommend that the health authorities involved devise regulations to improve manufacturing standards and regulate access to these drugs, ... However, Upjohn does not have this formulation listed as one of its products in the Physicians ’ De.& Reference, where it merely lists products containing one or the other of these drugs. Similarly, Lederle has registered a combination of tetracycline, salicylamide, acetophenetidine, phenylephrine, and chlorpheniramine in Central America under the brand name “Acropon,”
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