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Allelopathic activity of saponins exctracted from Rhododendron luteum Sweet

... хроматография в фармации и клинической биохимии. Мир, Москва. 370 Modern Phytomorphology 4 (2013) Allelopathic activity of saponins exctracted from Rhododendron luteum Sweet Iryna M. Yezhel Abstract. Article deals with allelopathic activity of saponins exctracted from Rhododendron luteum Sweet leaves. Investigations show nonlinear correlation between
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Inhibition of c-Abl kinase activity renders cancer cells highly sensitive to mitoxantrone.

... constitutively active c-Abl expression. This aberrant kinase activity results in enhanced proliferation, which can be inhibited with imatinib. Imatinib is an ATP-competitive inhibitor stabilizing inactive c-Abl conformation [8]. The kinase activity of c-Abl is increased after DNA damage and then increases the activity of Atm and Atr [9]. Treatment with imatinib ... (Promega, Madison, WI, USA). The luciferase activity was quantified with the aid of a hybrid capture luminometer (Digene, Gaithersburg, 2 August 2014 | Volume 9 | Issue 8 | e105526 Mitoxantrone and c-Abl Kinase Activity MD, USA). Luciferase readings were divided by WST-1 value to obtain normalized reporter activity. Statistics To evaluate differences ... is not able to alter these levels (Figure 2). Cells treated with 0.6 mM MX and 0.8 mM DXR increased the caspase activity 2.5 fold, whereas the MX + imatinib combination treatment increased the activity 4 fold. Imatinib did not increase the activity induced by DXR alone. Time-lapse microscopy Images were captured in one hour interval for 72 hours with IncuCyte
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Study of dynamics of level of physical preparedness of students.

... dynamics of level of physical preparedness of students. The dynamics of level of physical preparedness of students is studied in the article. A tendency is marked to the decline of level of physical preparedness of students of 1-3 courses. Methodical recommendations are presented on the improvement of the system of organization of physical education of ... national university. The dynamics of indexes of physical preparedness of students 1, 2, 3 courses of different years of teaching is studied. Principal reasons of decline of level of physical preparedness of students are certain. There are recommendations the department of physical education in relation to physical preparedness of students. студенты, ... часи кількість публікацій з вивчення проблеми організації фізичного виховання студентів ВНЗ зросла, проте залишається багато наукових і © Коваленко Ю.О., 2010 56 dynamics, physical практичних питань, вирішення яких може мати суттєве значення для розуміння механізмів підвищення рівня здоров’я юнаків та дівчат, і як наслідок рівня їх фізичної підготовленості. Робота
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Antitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One-Based Synthetic Small Molecule In Vitro and In Vivo.

... antitumor activity, this activity has rarely been explored because their synthetic difficulty makes the unavailable. Recently, a highly efficient and expedient protocol for synthesis of 5-hydoxy-1H-pyrrol2-(5H)-ones was developed [9], and this protocol permits the synthesis of a variety of this compound’s derivatives for the study of their antitumor activity. In ... DOI:10.1371/journal.pone.0128928 June 4, 2015 9 / 15 Antitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One Discussion In this study, we explored the antitumor activity of the derivatives of 5-hydoxy-1H-pyrrol-2(5H)-one and demonstrated that 1d possessed a strong anti-proliferative activity toward a wide range of human cancer cell lines, and that ... that all the derivatives we synthesized exhibited some degrees of anti-proliferative activity, suggesting that both the Nheterocyclic scaffold and the side groups contribute to this activity. More importantly, we demonstrated that 1d possesses a potent tumor suppression activity using both in vitro cell culture and in vivo xenograft tumor models, suggesting
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Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors.

... is nearly identical to the one observed for DYRK1A/B and explains the observed inhibitory activity of AnnH75 for CLK1. Kinome profiling The selectivity of AnnH75 was profiled against a panel of 300 kinases at a concentration of 1 μM (Table A in S1 File). These activity assays identified CLK1, CLK4, haspin (gene symbol PLOS ONE | DOI:10.1371/journal.pone.0132453 ... given because % -activity values are not given in the reference. IC50 value taken from Cuny et al. [38] c doi:10.1371/journal.pone.0132453.t002 To compare the overall kinase inhibitor selectivity of AnnH75 and other inhibitors, we calculated a selectivity score (S) for each compound by dividing the number of target kinases (< 50% residual activity) by ... rate. Inhibition of DYRK1A activity in cell culture To evaluate the new harmine analogues for their capacity of inhibiting DYRK1A in cell culture experiments, we compared the effect of AnnH75 and other select compounds on the DYRK1A-catalysed phosphorylation of splicing factor 3b1 (SF3B1). Phosphorylation of SF3B1 on Thr434 closely reflects the cellular activity of
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Use of outdoor games in physical rehabilitation of children with a cerebral paralysis.

... основной группы здоровья. Доказано, что специально организованные подвижные игры на занятиях содействуют росту этих показателей. Vindiuk P.A., Volkova S.S. Use of outdoor games in physical rehabilitation of children with a cerebral paralysis. We considered the estimation of energy in children’s organism with cerebral paralysis. 16 children of secondary school
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Differential water mite parasitism, phenoloxidase activity, and resistance to mites are unrelated across pairs of related damselfly species.

... response including PO activity. Their major issue with PO activity was that with long term storage, even in -70°C temperature, PO activity could be degraded or spontaneously activated. There is no question that PO activity plays a role in insect innate immunity, but it is very species specific. There is a debate about the relevance of PO activity as a proxy ... less PO activity [20], and in Hetaerina americana (Fabricius) the larger individuals with larger wing spots had higher levels of PO activity [21]. In these circumstances, there is considerable variability in PO activity within species, some of which might relate to immunity either directly or indirectly [15]. Although the reliability of PO activity ... effect of species on potential PO activity (Fig. 2D). Argia moesta had significantly higher PO activity (F1,76 = 58.55, p
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Intra- and Interhemispheric Propagation of Electrophysiological Synchronous Activity and Its Modulation by Serotonin in the Cingulate Cortex of Juvenile Mice.

... the cerebral cortex is the generation of synchronized activity during normal sensory processing [16] and also during pathological conditions (e.g., seizures [17]). Disinhibition of the neocortex by blockers of GABAA receptors (bicuculline, picrotoxin) is especially effective in generating synchronous activity, both in vivo [18] and in vitro [19, 20, 21]. ... involving the generation and local propagation of this synchronized activity in motor cortical areas [18, 22, 23], including the propagation of epileptiform discharges across the corpus callosum [24, 25], there is still little information about the propagation of this kind of electrical activity in other cortical areas. Among other afferent systems, the ... velocities were within the same range as the propagation velocities described previously for epileptiform activity or interictal discharges induced by the block of GABAergic receptors [24], but were much faster than the propagation of epileptiform activity induced by bathing the slices in zero Mg2+ extracellular solution [52, 53], a condition in which
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The effect of aquatic plyometric training with and without resistance on selected physical fitness variables among volleyball players

... Journal of Physical Education and Sport ® - JPES, 11(2), Art # 31, pp.205-210, 2011 E- ISSN 2066-2483 P-ISSN 1582-8131 © JPES Original Article The effect of aquatic plyometric training with and without resistance on selected physical fitness variables among volleyball players K. KAMALAKKANNAN1 , DR. KAUKAB AZEEM2, DR. C. ARUMUGAM3 1 Director of Physical ... ARUMUGAM3 1 Director of Physical Education, Arunai Engineering College, Tiruvannamalai, Tamil nadu, India. 2Lecturer, Physical Education Department, King Fahd University of Petroleum & Minerals, S.A 3 Asst Prof Dept of sports coaching, Tamilnadu Physical Education and Sports University, Chennai, India. Published online:: June 30 2011 (Accepted for publication ... 2011) ES Abstract The purpose of this study is to analyze the effect of aquatic plyometric training with and without the use of weights on selected physical fitness variables among volleyball players. To achieve the purpose of these study 36 physically active undergraduate volleyball players between 18 and 20 years of age volunteered as participants. The participants were
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Effects of solar activity on noise in CALIOP profiles above the South Atlantic Anomaly

... 11-year cycle of solar activity (with a 1year lag). By analyzing the geographic distribution of noisy profiles, we are able to reproduce known findings about the SAA region. Over the considered period, it shifts westward by 0.3◦ year−1 , and changes in size by 6◦ meridionally and 2◦ zonally, becoming larger with weaker solar activity. All results are ... the SAA, which impacts the noise in CALIOP observations, is anticorrelated with the 11-year cycle of solar activity (with 1 year lag) (Fürst et al., 2009). This anticorrelation is due to heating of the exo- and thermosphere during maximum solar activity, which leads to a higher neutral density in the altitudes below affected by the SAA (e.g., Qian et ... al., 2006). This increases the absorption and deflection of trapped particles, resulting in a lower particle flux compared to when the solar activity is minimum (Dachev et al., 1999). Thus during maximum solar activity the flux of energetic particles below CALIOP is smaller. The 1-year lag reflects the time needed for the atmosphere to react to incoming
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Associations of sedentary behaviour, physical activity, blood pressure and anthropometric measures with cardiorespiratory fitness in children with cerebral palsy.

... difference in physical activity intensity between tertiles, p
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Monofractal or multifractal: a case study of spatial distribution of mining-induced seismic activity

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Characteristics of intercommunications of sport results and indexes of technique and tactic of competition activity of highly qualified sportsmen of karate-do.

... стиль, двобій, кореляція, особливості. BaranovM.V.,MalyarenkoA.T.Characteristics of intercommunications of sport results and indexes of technique and tactic of competition activity of highly qualified sportsmen of karate-do. The effectiveness of the individualization of technical and tactical training of athletes of karate-offensive, maneuver, and
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Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis.

... a pressure cooker for 5 minutes with 0.01 M citrate buffer (pH 6.0). To quench endogenous peroxidases activity, slides were incubated in 0.3% hydrogen peroxide (v/v) in Tris-buffered saline (TBS) for 30 minutes at room temperature (RT). Nonspecific activity was blocked using the appropriate normal blocking serum (10% normal serum (vol/vol; Biosera) ... Leydig cells with mature cells only forming near the rete testis where Sertoli-like cells remain [21]. Once formed, activity of the adult Leydig cells is dependent on LH and osteocalcin and in the absence of either hormone Leydig cell activity is markedly reduced although cell numbers are largely maintained [27,54]. Results reported here now show for ... cells around the rete testis following Sertoli cell ablation would be consistent with the Sertoli cell-like activity of the rete epithelial cells seen in neonatal mice [21] and suggests that these cells may retain a degree of Sertoli cell functional activity beyond puberty. It is less clear why Leydig cells are also retained or re-localize to the sub-capsular
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Abundance, composition and activity of ammonia oxidizer and denitrifier communities in metal polluted rice paddies from South China.

... lead to an increase in denitrifying activity but do not change the composition of the nirK community [65,66]. An inhibition of denitrification activity had been widely recognized under highly elevated Cu level in soil though soil pH could be an important factor for denitrifying activity. A decrease in denitrification activity in soils spiked or polluted ... fingerprinting and enzyme activity assays and comparisons to adjacent non-polluted soils, we examined changes in the abundance and activity of ammonia oxidizing and denitrifying communities of rice paddies in two sites with different metal accumulation situation under long-term pollution from metal mining and smelter activities. Potential nitrifying activity was ... amendment. PLOS ONE | www.plosone.org 8 July 2014 | Volume 9 | Issue 7 | e102000 Microbial Communities in Metal Polluted Paddy Figure 4. The potential nitrifying activity (a) and denitrifying activity (b) of the background (Blank) and polluted (Shaded) soils in DX and DBS sites. Different lowercase characters indicate significant difference (p,0.05) between
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THE MORPHOBATHYMETRIC FEATURES OF THE CUCIULAT LAKES (SĂLAJ COUNTY) AND THEIR WATERS’ PHYSICAL CHARACTERISTICS

... bathymetry and also in some of their physical characteristics. The identification of the lakes’ morphobathymetric features and of the waters’ physical characteristics relied on measurements taken in the summer of 2009 (August 17). In the field, we used a Hannah HI 9828 multiparameter instrument to measure the waters’ physical characteristics and a GPS ... both natural and anthropic. 145 The determination of the lakes’ bathymetric elements and of their waters’ physical features was achieved on the basis of the measurements carried out on August 17, 2009. In order to measure the depth and the physical characteristics of the lakes’ waters we used a Hannah HI 9828 multiparameter instrument, and in order ... To capture the best possible spatial variation of the mentioned characteristics, we used interpolation as modeling method. Keywords: lake bathymetry, Cuciulat quarry, waters’ physical characteristics 1. Introduction The two lake units (Cuciulat I and Cuciulat II) are situated in the area of the lime quarry from Cuciulat, in between the localities
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Quantitative Analysis of Torso FDG-PET Scans by Using Anatomical Standardization of Normal Cases from Thorough Physical Examinations.

... of post-injection rest, and they were instructed to breathe shallowly during the scan to minimize image blurring. To restrain muscle activity, the imaging protocol of FDG-PET scan was followed by the guideline [20]. The activity of normal brown fat was considered as normal variation in the normal database. Image registration A novel image registration ... Hara T, Kobayashi T, Ito S, Zhou X, Katafuchi T, Fujita H (2015) Quantitative Analysis of Torso FDG-PET Scans by Using Anatomical Standardization of Normal Cases from Thorough Physical Examinations. PLoS ONE 10(5): e0125713. doi:10.1371/journal.pone.0125713 Academic Editor: John A D Aston, University of Cambridge, UNITED KINGDOM Received: September ... diagnostic method for detecting cancers because the lesions utilize higher glucose than normal regions. Standardized uptake value (SUV), which is defined as the regional tissue radioactivity concentration normalized for the injected dose and body surface area, is a semi-quantitative measurement of FDG metabolism[1, 2]. However, the problem with the SUV is
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Home free? The (After)Effects of Imprisonment on Women's Bodies, Physical and Mental Health and Identity

... Women’s Bodies, Physical and Mental Health and Identity Laura shantz & sylvie frigon Introduction The number of women imprisoned in Canada and elsewhere in the world has grown significantly in recent years.[1,2,3] As such, increasing numbers of women are exposed to carceral practices which rely on disciplinary routines to regulate physical activities, ... town square. The physical location of punishment has changed, as well as its ultimate goal, but punishments are still situated on the body, and continue to have real and lasting effects on prisoners’ corporeality. As forms of punishment changed, so too did individual responses to it. The condemned had no recourse in the face of early physical punishments; ... detrimental to an individual’s physical and mental health, it can provide a refuge for women who have been homeless, addicted to drugs or victimized. Prison provides a warm place to sleep and access to regular meals, medical services and dental care, all of which women might not have otherwise. The prison also protects women from the physical violence of families,
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LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.

... phosphorylation activity for the T1348N mutant clearly allow us to conclude that the T1348N inhibits kinase activity. Taken together, these data show that the capacity for GDP/GTP binding is essential for LRRK2 kinase activity, but that the specific guanine nucleotide bound to LRRK2 ROC does not play a modulatory role on LRRK2 kinase activity. Therefore ... phosphorylation activity of LRRK2 is unchanged when the LRRK2 guanine nucleotide binding pocket is previously saturated with various nucleotides, in contrast to the greatly reduced activity measured for the guanine nucleotide binding site mutant T1348N. Interestingly, when nucleotides were incubated with cell lysates prior to purification of LRRK2, kinase activity ... Our data show that an intact ROCGTPase domain is required for LRRK2 kinase activity and that kinase activity remains unchanged upon direct application of GDP compared to GTP or non-hydrolyzable GTP analogues, reconciling discrepancies in previous reports. Results LRRK2 kinase activity of the affinity purified protein is not altered upon co-incubation
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Antimicrobial and Cytotoxic Activity of Three Bitter Plants-Enhydra fluctuans, Andrographis Peniculata and Clerodendrum Viscosum.

... of 06 to 08 mm in diameter (Table 2). In antifungal activity test, ALE produced zone of inhibition between 07 to 15 mm against Aspergillus niger, Fusarium sp and Aspergillus fumigatus whereas MLE exhibited activity against Aspergillus niger and Fusarium sp (Table 3). Both MLA and ALA showed moderate activity only against Human-3 sp and produced inhibition ... were tested separately for antibacterial activity by disc diffusion assay method.16 Kanamycin disc (30 μg/disc) and Nystatin disc (100 μg/disc) were used as positive antibacterial and antifungal control, respectively. Blank disc impregnated with the respective solvent was used as negative control. The antibacterial activity of each extract was tested against ... range 06 to 14 mm. ALA and MLA showed activity against Sarcina lutea, Escherichia coli and Shigella sonnei and produced zone of inhibition between 06 to 11 mm (Table 2). MLC and ALC were found inactive against the tested bacteria at concentration of 200 μg/disc, whereas at concentration of 400 μg/disc, it showed mild activity against Sarcina lutea, Escherichia
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Antimicrobial activity of Lippia origanoides and Lippia rotundifolia oils against enterobacteria isolated from poultry.

... 2015 Comunicação [Communication] Atividade antimicrobiana do óleo essencial de Lippia origanoides e Lippia rotundifolia frente a enterobactérias isoladas de aves [Antimicrobial activity of Lippia origanoides and Lippia rotundifolia oils against enterobacteria isolated from poultry] D.S. Souza, A.C. Almeida*, V.A. Andrade, N.A. Marcelo, I.L. Azevedo, ... convencionais. Palavras-chave: óleos essenciais, produtos naturais, promotores de crescimento, frangos de corte ABSTRACT The aim of this study was to evaluate the antimicrobial activity of essential oils on enterobacteria Escherichia coli and Staphylococcus aureus isolated from poultry fecal samples in the cloaca from 49 laying hens. To analyze the antimicrobial ... e UFMG/PRPq pelo suporte financeiro e concessão de bolsas de pesquisas na execução deste projeto. REFERÊNCIAS ANDRADE ,V.A., ALMEIDA, A.C., SOUZA, D.S. et al. Antimicrobial activity and acute and chronic toxicity of Lippia origanoides. Pesqui. Vet. Bras., v.34, p.1153-1161, 2014. BRASIL. Ministério da Agricultura, Pecuária e Abastecimento. Instrução
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Physical Stress Echocardiography: Prediction of Mortality and Cardiac Events in Patients with Exercise Test showing Ischemia.

... demonstrated the diagnostic accuracy and prognostic value of physical stress echocardiography in coronary artery disease. However, the prediction of mortality and major cardiac events in patients with exercise test positive for myocardial ischemia is limited. Objective: To evaluate the effectiveness of physical stress echocardiography in the prediction of ... is a retrospective cohort in which 866 consecutive patients with exercise test positive for myocardial ischemia, and who underwent physical stress echocardiography were studied. Patients were divided into two groups: with physical stress echocardiography negative (G1) or positive (G2) for myocardial ischemia. The endpoints analyzed were all-cause mortality ... independent predictors of mortality were: age, diabetes mellitus, and positive physical stress echocardiography (hazard ratio: 2.69; 95% confidence interval: 1.20 – 6.01; p = 0.016). The independent predictors of major cardiac events were: age, previous coronary artery disease, positive physical stress echocardiography (hazard ratio: 2.75; 95% confidence interval:
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Detection of esophageal squamous cell carcinoma by cathepsin B activity in nude mice.

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Physical and psychological stress have similar effects on gastric acid and pepsin secretions in rat

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Obesity, diet, and physical activity

... term and that the promotion of healthy diet and physical activity should not exclusively focus on obesity control but on changing inadequate dietary and physical activity patterns, as well. Promotion of Physical Activity as an Everyday Lifestyle The New Paradigm in Physical Activity Promotion: Moderate Physical Activity 33. Sedentary lifestyles are not simply ... intake. Physical Inactivity 12. Physical activity, defined as “any bodily movement produced by skeletal muscles that results in a substantial increase over the resting energy expenditure,” ranges from the performance of occupational work and household chores to recreational physical activity, such as sports and exercise. Decreased physical activity ... years, and a low level of physical activity during periods of leisure in adults has been shown to be predictive of substantial weight gain (> 5 kg) in 5 years’ time. A number of studies conducted in Latin America have also reported that inactivity is strongly associated with obesity. 2 One hour or more of moderate/intense physical activity, five days a
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